Global Minima: it is referenced here as ultimate goal of our life and that is getting Moksha.

Local minima: It is the state of life were we think that we are in the state of Global minima but in reality it live in an illusion and such state is called local minima.
[Global and local minima in their exact sense represents the conformational state of molecules on the energy landscape]

First paragraph elucidates that people try to find the Moksha and they use different paths to achieve it.
(कुछ संत बने भभूत रमा कर , कुछ चरण पूज सिन्दूर सजा कर)
this line says that people follow all the ways possible to achieve mokhsha but life is as mysterious as ever and no one is able to find the real way to reach to God and getting Global minima.